TMEM16A blockers T16Ainh‐A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo

Autor: Naoto Fujii, Tatsuro Amano, Glen P. Kenny, Toby Mündel, Tze‐Huan Lei, Yasushi Honda, Narihiko Kondo, Takeshi Nishiyasu
Rok vydání: 2022
Předmět:
Zdroj: Experimental Physiology. 107:844-853
ISSN: 1469-445X
0958-0670
DOI: 10.1113/ep090521
Popis: What is the central question of this study? Do transmembrane member 16A (TMEM16A) blockers modulate the activation of heat loss responses of sweating and cutaneous vasodilatation? What are the main finding and its importance? Relative to the vehicle control site, TMEM16A blockers T16Ainh-A01 and benzbromarone had no effect on sweat rate or cutaneous vascular conductance during whole-body heating inducing a 1.1 ± 0.1°C increase in core temperature above baseline resting levels. These results suggest that TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation during whole-body heat stress.Animal and in vitro studies suggest that transmembrane member 16A (TMEM16A), a Ca
Databáze: OpenAIRE
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