The Dysexecutive Syndrome of Alzheimer's Disease: The GREFEX Study
| Autor: | Olivier Godefroy, Chrystèle Mosca, Marc Verny, Hermine Lenoir, Eric Bretault, Olivier Martinaud, Martine F. Roussel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Disease Motor Activity Neuropsychological Tests Audiology Executive Function Alzheimer Disease medicine Humans Dementia Attention Psychiatry Aged Dysexecutive syndrome Cognitive domain General Neuroscience Neuropsychology Cognition General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Female Geriatrics and Gerontology Alzheimer's disease Psychology Hypoactivity |
| Zdroj: | Journal of Alzheimer's Disease. 42:1203-1208 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-140585 |
| Popis: | Background Dysexecutive disorders are common in early-stage Alzheimer's disease (AD) but have yet to be characterized in detail. Objective The objectives of the present study based on validated diagnostic criteria were to determine the frequency and characterize the profile of behavioral and cognitive dysexecutive disorders in AD. Methods 102 patients with AD (mild: n = 92; moderate: n = 10; mean MMSE score: 23.2) were examined with the GREFEX battery. Neuropsychological data were interpreted within a validated framework based on the performance levels of 780 control participants from the GREFEX study. Results Dysexecutive syndrome was observed in 87.5% (95%CI: 79-96) of the AD patients (p = 0.0001). The dysexecutive disorder profile was characterized by prominent impairments of planning, inhibition flexibility and generation in the cognitive domain (p = 0.0001 as compared to controls for all) and global hypoactivity in the behavioral domain (p = 0.0001 as compared to controls). Conclusions Dysexecutive syndrome is observed in over 80% of AD patients and has a distinct profile. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|