Combined modality treatments in pancreatic cancer
| Autor: | Nicola Silvestris, Tiziana Latiano, L. Nanni, Giuseppe Colucci, Pierluigi Di Sebastiano, Saverio Cinieri, Gabriele Di Maggio, Lucia Lombardi, Michele Troiano, Evaristo Maiello |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Oncology medicine.medical_specialty business.industry medicine.medical_treatment Mortality rate Clinical Biochemistry Chemoradiotherapy Adjuvant medicine.disease Combined Modality Therapy Clinical trial Pancreatic Neoplasms Pancreatic cancer Internal medicine Drug Discovery medicine Adjuvant therapy Molecular Medicine Humans business Survival rate Neoadjuvant therapy Chemoradiotherapy Neoplasm Staging |
| Zdroj: | Expert opinion on therapeutic targets. 16 |
| ISSN: | 1744-7631 |
| Popis: | Introduction: Of all the carcinomas, pancreatic carcinoma (PC) has the highest mortality rate, with a 1- and 5-year survival rate of 25% and less than 5% respectively. This is regardless of the stage at diagnosis. Areas covered: In this review relevant literature assessing the evidence regarding preoperative and adjuvant chemoradiotherapy (CRT) is discussed. Furthermore, new therapeutic approaches are summarized, while the future direction regarding the multimodality approach to PC is also discussed. Expert opinion: The role of combined-modality therapy for PC is continuously evolving. There have been several recent developments, as well as the completion of major, multi-institutional clinical trials. One of the challenges for the busy clinician is to appreciate the variation in staging, surgical expertise, and application of either definitive CRT or neo-adjuvant CRT for local and/or borderline disease. |
| Databáze: | OpenAIRE |
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