IL-37 impairs host resistance to Listeria infection by suppressing macrophage function
| Autor: | Jianhua Yang, Shao Bo Su, Juanjuan Shou, Tianshu Yang, Yongguang Hu, Mengmeng Zhao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biophysics Apoptosis Biology medicine.disease_cause Listeria infection Biochemistry Microbiology Sepsis 03 medical and health sciences Listeria monocytogenes medicine Animals Humans Macrophage Listeriosis Molecular Biology Cells Cultured Disease Resistance Mice Inbred BALB C Host resistance Macrophages Cell Biology Flow Cytometry medicine.disease Survival Analysis Bacterial Load Disease Models Animal 030104 developmental biology medicine.anatomical_structure Liver Host-Pathogen Interactions Immunology Cytokines Bone marrow Function (biology) Interleukin-1 |
| Zdroj: | Biochemical and Biophysical Research Communications. 485:563-568 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2016.11.002 |
| Popis: | Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infection. In mice model of systemic infection, we found that mice treated with IL-37 were more sensitive to Lm infection compared with PBS-treated mice. This reduced resistance to Lm in IL-37-treated mice is accompanied with increased bacterial burden and liver damage. Serum levels of colony-stimulating factors were decreased in IL-37-treated mice. IL-37 treatment reduced bactericidal ability of bone marrow derived macrophages (BMDMs) in vitro, which contribute to the inability of IL-37-treated mice to combat Lm infection. Furthermore, increased apoptosis was observed in Lm-infected macrophages treated with IL-37. Increased macrophage apoptosis reduced percentage in liver macrophages was observed in IL-37-treated mice following Lm infection. These results indicate the negative regulatory effect of IL-37 on host resistance during immune defense against Lm. |
| Databáze: | OpenAIRE |
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