Submacular Combination Treatment for Management of Acute, Massive Submacular Hemorrhage in Age-Related Macular Degeneration
| Autor: | Jean-Pierre Hubschman, Steven D. Schwartz, Sumit P Shah, Christine R. Gonzales |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Pars plana medicine.medical_specialty Visual acuity medicine.medical_treatment Visual Acuity Angiogenesis Inhibitors Vitrectomy Antibodies Monoclonal Humanized Tissue plasminogen activator Macular Degeneration chemistry.chemical_compound Combined treatment Fibrinolytic Agents Ranibizumab Age related Ophthalmology medicine Humans Fluorescein Angiography Aged Aged 80 and over business.industry Antibodies Monoclonal Retinal Hemorrhage Retinal Aptamers Nucleotide Macular degeneration medicine.disease Combined Modality Therapy Recombinant Proteins eye diseases medicine.anatomical_structure chemistry Tissue Plasminogen Activator Acute Disease Drug Therapy Combination Female sense organs medicine.symptom business Tomography Optical Coherence medicine.drug |
| Zdroj: | Ophthalmic Surgery, Lasers and Imaging Retina. 40:308-315 |
| ISSN: | 2325-8179 2325-8160 |
| DOI: | 10.3928/15428877-20090430-16 |
| Popis: | A surgical technique is described combining submacular anti-vascular endothelial growth factor (anti-VEGF) and recombinant tissue plasminogen activator (r-TPA) with pneumatic displacement of massive submacular hemorrhage in age-related macular degeneration. An 84-year-old man with a large, acute submacular hemorrhage secondary to age-related macular degeneration underwent combination vitrectomy, submacular anti-VEGF and r-TPA injection with pneumatic displacement of the hemorrhage. At the last follow-up visit, 7 months after surgery, visual acuity was 20/80 with a small fibrovascular pigment epithelial detachment and atrophic retinal pigment epithelial changes. A 77-year-old woman with known age-related macular degeneration underwent a similar surgical procedure for a similar acute, large submacular hemorrhage related to age-related macular degeneration. Nine months after surgery, the visual acuity was 20/70-1. Combination submacular anti-VEGF therapy delivered at the time of pars plana vitrectomy and submacular tissue plasminogen activator assisted hemorrhage displacement may be a viable treatment strategy for the management massive submacular hemorrhage. [Ophthalmic Surg Lasers Imaging 2009;40:308-315.] |
| Databáze: | OpenAIRE |
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