Anxiety and nicotine dependence: Emerging role of the habenulo-interpeduncular axis
| Autor: | Andrew R. Tapper, Susanna Molas, Rubing Zhao-Shea, Steven R. DeGroot |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Interpeduncular nucleus Corticotropin-Releasing Hormone medicine.medical_treatment Interpeduncular Nucleus Emotions Receptors Nicotinic Toxicology Article 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Humans Nicotine dependence Pharmacology Habenula Ventral Tegmental Area Tobacco Use Disorder medicine.disease Anxiety Disorders 030104 developmental biology Nicotine withdrawal Anxiogenic Chronic nicotine Smoking cessation Anxiety Medial habenula medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Popis: | While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)–interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb–IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal. Insights into how this circuit interconnects with regions more classically associated with anxiety, and how chronic nicotine exposure induces neuroadaptations resulting in an anxiogenic state, may thereby provide novel strategies and molecular targets for therapies that facilitate smoking cessation, as well as for anxiety relief. |
| Databáze: | OpenAIRE |
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