Relevance of MICA antibodies in acute humoral rejection in renal transplant patients
| Autor: | Jaume Martorell, M. Sole, M.A. Millán, Marta Crespo, O. Viñas, Federico Oppenheimer, M.G. Ercilla, M. Lopez-Cobos, Nuria Amézaga |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Graft Rejection
Immunology Transfection Cell Line Flow cytometry Isoantibodies medicine Humans Immunology and Allergy Prospective Studies Typing Prospective cohort study Kidney transplantation Transplantation Kidney biology medicine.diagnostic_test business.industry Histocompatibility Antigens Class I medicine.disease Kidney Transplantation Recombinant Proteins stomatognathic diseases surgical procedures operative medicine.anatomical_structure Acute Disease Chronic Disease biology.protein Antibody business |
| Zdroj: | Transplant Immunology. 17:39-42 |
| ISSN: | 0966-3274 |
| DOI: | 10.1016/j.trim.2006.09.016 |
| Popis: | The presence of MICA antibodies was examined in eleven patients diagnosed with AHR. MICA typing was performed in both recipients and donors. Sera were collected sequentially: pre-transplant, at the AHR episode and at follow-up. Sera from 30 patients with functioning graft were also analysed. A stable MICA()008 transfected cell line was used as target to identify MICA antibodies. MICA antibodies were not detected pre-transplant nor post-transplant in patients receiving a compatible graft. MICA antibodies were detected post-transplant AHR in patients receiving an incompatible graft. The persistence of MICA antibodies was associated with chronic graft dysfunction in 3 of 4 patients in this series; although it was not always associated with the graft loss in treated AHR. None of the 30 patients in the control group with long-term functioning grafts showed antibodies to MICA()008. This report provides some insights of the relevance of MICA antibodies in AHR. |
| Databáze: | OpenAIRE |
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