Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report
| Autor: | Francesco Fortarezza, Gerardo Cazzato, Antonio d’Amati, Andrea Marzullo, Teresa Lettini, Leonardo Resta, Gennaro Cormio, Federica Pezzuto, Gabriella Serio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Medicine (General) Clinical Biochemistry Mesonephric Adenocarcinoma carcinosarcoma Case Report Ovary mesonephric adenocarcinoma Mesonephric duct 03 medical and health sciences 0302 clinical medicine R5-920 Carcinosarcoma medicine Carcinoma gynecological pathology Mesonephric Remnants mesonephric-like carcinoma business.industry medicine.disease mesonephric carcinosarcoma female genital diseases and pregnancy complications Serous fluid 030104 developmental biology medicine.anatomical_structure ovarian cancer 030220 oncology & carcinogenesis pathology Ovarian cancer business |
| Zdroj: | Diagnostics, Vol 11, Iss 827, p 827 (2021) Diagnostics |
| ISSN: | 2075-4418 |
| Popis: | Mesonephric adenocarcinomas are rare tumors of the female genital tract, thought to arise from embryonic mesonephric remnants, primarily in the cervix and vagina. Conversely, endometrial and ovarian mesonephric adenocarcinomas may have a different pathogenesis, probably originating from transdifferentiated Müllerian carcinomas, as demonstrated by the association of these neoplasms with endometriosis and ovarian serous tumors. For this reason, in the endometrium and in the ovary, they are defined as “mesonephric-like adenocarcinomas”. Some cases of mesonephric carcinomas of the female genital tract have been reported to show a sarcomatous component and have been defined as “mesonephric carcinosarcomas”, characterized by poor prognosis and high metastatic behavior, but this entity has never been described in the ovary. The case herein presented is of a 74-year-old female with abdominal discomfort and a complex ovarian mass. Histological and immunohistochemical analysis showed features of ovarian mesonephric-like carcinoma combined with a low-grade serous component, in support of the theory of a Müllerian origin of these neoplasms. The tumor also revealed foci of chondrosarcomatous differentiation, never before reported in the ovary, showing a similar immunohistochemical profile to the mesonephric-like elements. This work thus describes the first reported case of ovarian mesonephric-like carcinosarcoma. |
| Databáze: | OpenAIRE |
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