Progress in understanding the molecular functions of DDX3Y (DBY) in male germ cell development and maintenance
| Autor: | Oxana M. Olenkina, Vladimir E Adashev, Ludmila V. Olenina, Alexei A. Kotov, Baira K Godneeva |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male endocrine system Health (social science) Transcription Genetic Somatic cell Biology Models Biological General Biochemistry Genetics and Molecular Biology Germline 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Induced pluripotent stem cell Mitosis Azoospermia factor 030219 obstetrics & reproductive medicine General Medicine Sertoli cell Spermatozoa Cell biology 030104 developmental biology medicine.anatomical_structure Stem cell Germ cell RNA Helicases |
| Zdroj: | Bioscience trends. 11(1) |
| ISSN: | 1881-7823 |
| Popis: | Human DDX3 paralogs are housed on the X chromosome (DDX3X) as well as in the non- recombining region Yq11 of the Y-chromosome (DDX3Y or DBY). A gene encoding RNA helicase DDX3Y is located in the AZoospermia Factor a (AZFa) region of the Y-chromosome and expressed only in male germ cells. Deletions encompassing the DDX3Y gene lead to azoospermia and cause Sertoli Cell-Only Syndrome (SCOS) in humans. SCOS is characterized by a complete germ cell lack with preservation of somatic Sertoli cells. This review summarizes current advances in the study of DDX3Y functions in maintenance and development of early male germ cells. Data obtained from a mouse xenotransplantation model reveals that DDX3Y expression is enough to drive germ cell differentiation of AZFa-deleted human induced pluripotent stem cells (iPSCs) and for activation of the specific set of germline developmental genes. Results achieved using the testes of Drosophila demonstrate that DDX3Y homolog Belle is required cell-autonomously for mitotic progression and survival of germline stem cells and spermatogonia as the upstream regulator of mitotic cyclin expression. |
| Databáze: | OpenAIRE |
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