Electricity Induced Rhodium-Catalyzed Oxidative C–H/N–H Annulation of Alkynes with Arylhydrophthalazinediones

Autor:	Partha Pratim Sen, Rashmi Prakash, Sudipta Raha Roy
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:4530-4535
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c01542
Popis:	The development of stoichiometric oxidant-free regioselective annulation protocol is a challenging aspect in organic synthesis. Herein, we disclose electricity as a greener oxidant for the C-H/N-H annulation to construct cinnolines using rhodium(III) catalyst under mild conditions. A detailed mechanistic investigation revealed the possibility of both Rh(III/I) and Rh(III/IV) catalytic cycles for the formation of annulated product. Exclusive regioselectivity, diverse substrate scope, and commercially available cheap graphite electrodes are key features of this protocol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b07257eca9b580249e3aa24573345af https://doi.org/10.1021/acs.orglett.2c01542 Zobrazit plný text záznamu