Effects of the new class-III antiarrhythmic drug D-sotalol on contractile function of postischemic myocardium
| Autor: | Hans Martin Hoffmeister, Müller S, Seipel L |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Inotrope
Male medicine.medical_specialty Cardiac output Ischemia Hemodynamics Coronary Disease Contractility Heart Rate Internal medicine medicine Animals Pharmacology Ejection fraction business.industry Sotalol Rats Inbred Strains Stereoisomerism Stroke volume medicine.disease Myocardial Contraction Rats Anesthesia cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 17(4) |
| ISSN: | 0160-2446 |
| Popis: | The hemodynamic effects of the new class-III antiarrhythmic drug D-sotalol (2 mg/kg i.v.) on postischemic myocardium were investigated in comparison with the actions of the racemic D,L-sotalol (2 mg/kg i.v.) in rats. Drug infusion (7 min) was started 20 min after 3 x 4 min of global ischemic injury (oxygen deficiency). The left ventricular isovolumic pressure-generating capacity at the beginning of infusion was reduced by 15%, indicating postischemic dysfunction. Infusion of D-sotalol caused a highly significant (p less than 0.01) reduction of the left ventricular pressure-generating capacity (to 58 +/- 5%), as well as of the dp/dtmax (to 21 +/- 3%). Stroke volume (to 66 +/- 6%), ejection fraction (to 62 +/- 7%), and cardiac output (to 51 +/- 6%) were also decreased (p less than 0.01). Fifteen minutes after infusion a partial renormalization of the hemodynamic measures (dp/dtmax 41 +/- 5%; stroke volume 94 +/- 8%) was observed. Infusion of the racemic D,L-sotalol caused similar hemodynamic changes (left ventricular pressure-generating capacity 60 +/- 2%, dp/dtmax 25 +/- 2%), indicating its cardiodepressant action. In contrast to prior findings on normal myocardium, our present results indicate that D-sotalol, a potential new class-III antiarrhythmic drug, has a considerable negative inotropic effect on postischemic myocardium. |
| Databáze: | OpenAIRE |
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