Subclinical central inflammation is risk for RIS and CIS conversion to MS
Autor: | Roberto Furlan, Gianvito Martino, Caterina Motta, Simone Rossi, Valeria Studer, Giorgio Germani, Diego Centonze, Giulia Macchiarulo, Annamaria Finardi |
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Přispěvatelé: | Rossi, S, Motta, C, Studer, V, Macchiarulo, G, Germani, G, Finardi, A, Furlan, R, Martino, Gianvito, Centonze, D. |
Rok vydání: | 2015 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty intrathecal inflammation Inflammation Asymptomatic Proinflammatory cytokine Multiple Sclerosis Relapsing-Remitting Cerebrospinal fluid medicine Humans Subclinical infection relapse Clinically isolated syndrome IL-8 business.industry Multiple sclerosis Interleukin-8 radiologically isolated syndrome Multiple Sclerosis Chronic Progressive progression medicine.disease Neurology Disease Progression Biomarker (medicine) Female Settore MED/26 - Neurologia Neurology (clinical) medicine.symptom business Biomarkers Demyelinating Diseases Follow-Up Studies |
Zdroj: | Multiple Sclerosis Journal. 21:1443-1452 |
ISSN: | 1477-0970 1352-4585 |
Popis: | Background: Subtle diffuse intrathecal inflammation is undetectable by conventional neuroimaging, and could influence multiple sclerosis (MS) disease course. Objective: To explore the role of subclinical persisting intrathecal inflammation in radiologically isolated syndrome (RIS) or clinically isolated syndrome (CIS) conversion to MS, and in early MS disease reactivation. Methods: One-hundred ninety-three subjects with RIS, CIS, relapsing–remitting (RR), or primary progressive (PP) MS were included, along with 76 matched controls. Cerebrospinal fluid (CSF) levels of interleukin-8 (IL-8), a major proinflammatory cytokine, were measured as a biomarker of intrathecal inflammation. Patients were followed up for 2 years. Clinical and imaging measures of disease progression were recorded. Results: High central contents of IL-8 were associated to clinical progression in subjects with RIS, and to the risk of conversion to MS in subjects with CIS. Asymptomatic intrathecal inflammation placed subjects at risk for MS conversion, even regardless lesion load. CSF IL-8 levels were higher in RR MS with high disease activity. Higher number of relapses in the first two years since diagnosis and shorter first inter-attack intervals were observed in patients with high levels of IL-8. Conclusion: IL-8 might provide utility in determining the presence of active intrathecal inflammation, and could be important in diagnostically undefined cases. |
Databáze: | OpenAIRE |
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