Longitudinal grey matter changes following first episode mania in bipolar I disorder: A systematic review
Autor: | Lakshmi N. Yatham, Ariana Cahn, Kamyar Keramatian, Trisha Chakrabarty, Christian W S Frysch |
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Rok vydání: | 2021 |
Předmět: |
Psychosis
Bipolar Disorder Bipolar I disorder Grey matter 03 medical and health sciences 0302 clinical medicine Region of interest analysis Neuroimaging Recurrence medicine Humans Bipolar disorder Gray Matter skin and connective tissue diseases First episode business.industry Brain medicine.disease Magnetic Resonance Imaging 030227 psychiatry Mania Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure sense organs medicine.symptom business 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Journal of Affective Disorders. 291:198-208 |
ISSN: | 0165-0327 |
Popis: | Background While widespread grey matter (GM) changes are seen in bipolar I disorder (BD-I), it is unclear how early in the illness such changes emerge. To date there has been little synthesis of findings regarding longitudinal grey matter changes early in the course of BD-I. We conducted a systematic review to examine the evolution of GM changes in BD-I patients following the first episode of mania (FEM). Methods Following PRISMA guidelines, we conducted a systematic review of studies examining longitudinal changes in GM volume (GMV), cortical thickness and/or surface area in BD-I patients following FEM. We qualitatively synthesized results regarding longitudinal GM changes in BD-I patients. Results Fifteen studies met inclusion criteria, all examining GMV changes. Longitudinal ACC volume decrease following FEM was the most replicated finding, but was only reported in 4 out of 7 studies that examined this region as part of a whole brain/region of interest analysis, with 2 of these positive studies using an overlapping patient sample. The impact of episode recurrence, medications, and other clinical factors was inconsistently examined. Limitations The literature regarding GM changes early in BD-I is highly inconsistent, likely due to heterogeneity in participant characteristics, imaging methodology/analysis and duration of follow up. Conclusions Though there was some suggestion that structural ACC changes may represent a marker for neuroprogression following FEM, results were too inconsistent to draw any conclusions. Larger longitudinal studies examining cortical thickness/surface area, and the influence of relevant clinical factors, are needed to better understand neuroprogression in early BD-I. |
Databáze: | OpenAIRE |
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