Intracranial aneurysms formation after radiotherapy for head and neck cancer: a 10-year nationwide follow-up study

Autor: Ko-Jung Chen, Pau-Chung Chen, Wei-Hsun Yang, Yao-Hsu Yang, Chun-Yu Cheng, Chia-Hsuan Lai, Ting-Chung Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
medicine.medical_treatment
Vasculopathy
Kaplan-Meier Estimate
0302 clinical medicine
Surgical oncology
Risk Factors
Head and neck cancer
Nasopharyngeal Carcinoma
Incidence
Hazard ratio
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Oncology
030220 oncology & carcinogenesis
Hypertension
cardiovascular system
Female
Radiology
Research Article
Adult
medicine.medical_specialty
Taiwan
Radiation Dosage
lcsh:RC254-282
03 medical and health sciences
Aneurysm
Sex Factors
Genetics
medicine
otorhinolaryngologic diseases
Humans
cardiovascular diseases
Risk factor
Aged
Proportional Hazards Models
Radiotherapy
business.industry
Cancer
Intracranial Aneurysm
medicine.disease
Radiation therapy
stomatognathic diseases
030104 developmental biology
Nasopharyngeal carcinoma
business
Follow-Up Studies
Zdroj: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
ISSN: 1471-2407
Popis: Background Intracranial aneurysms after radiotherapy (RT) have previously been reported. However, the majority of studies were case reports. Therefore, we performed a nationwide study to explore the risk of radiation-induced intracranial aneurysms. Methods This study included patients diagnosed with head and neck cancer (ICD9: 140–149, 161). Intracranial aneurysms formation was identified using the following ICD9 codes: nonruptured cerebral aneurysm (ICD9:4373), aneurysm clipping (ICD9:3951). Patients who did not receive curative treatment and those with intracranial aneurysms before the diagnosis of head and neck cancer were excluded. Results In total, 70,691 patients were included in the final analysis; they were categorized into the following three groups: nasopharyngeal carcinoma (NPC) with RT, non-NPC with RT, and non-NPC without RT. Patients in the NPC with RT group had the highest risk of developing intracranial aneurysms (hazard ratio (HR) 2.57; P
Databáze: OpenAIRE
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