Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks

Autor:	Sari Deketelaere, Gurkirat Kaur, Nicola Piens, Daan Deturck, Robin Depestel, Kristof Van Hecke, Christian V. Stevens, Vipan Kumar, Matthias D'hooghe
Rok vydání:	2022
Předmět:	Chemistry Organic Chemistry REARRANGEMENT SYNTHON ASYMMETRIC-SYNTHESIS TRANSFORMATION
Zdroj:	JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.4597
Popis:	In this study, the preparation of 4-imidoyl-, 4-oxiranyl-, and 4-propargyloxyphenyl-substituted beta-lactams as versatile building blocks in heterocyclic chemistry was realized. Efforts were made to deploy these polyvalent compounds for ensuing cyclization reactions en route to new bi- or polycyclic frameworks, which, in the case of a 3-chloro-4-propargyloxyphenyl-beta-lactam substrate, enabled the preparation of an unprecedented beta-lactam-fused benzotriazolo-oxazocane scaffold. The chemical structure of the latter polyheterocycle was unequivocally secured by means of X-ray analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b01495a39e6a596904a3374369f9606 https://doi.org/10.1002/jhet.4597 Zobrazit plný text záznamu