Multiple Myeloma Presenting with Autoimmune Autonomic Ganglionopathy
| Autor: | Yoshiki Nakae, Akiko Fukunaga, Yoshitomo Maesako, Nobuyoshi Arima, Yuta Terada, Toshinari Nakane, Kenichi Komatsu, Wataru Kishimoto, Osamu Higuchi, Sumie Tabata, Mizuki Hyuga |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
autoimmune autonomic ganglionopathy Case Report Autoimmune autonomic ganglionopathy autonomic disturbance Receptors Nicotinic Autonomic disorder Serology 030207 dermatology & venereal diseases 03 medical and health sciences Orthostatic vital signs 0302 clinical medicine hemic and lymphatic diseases Internal Medicine Neurological syndrome medicine Humans Ganglia Autonomic Multiple myeloma Autoantibodies biology business.industry Antibody titer General Medicine medicine.disease multiple myeloma Autonomic Nervous System Diseases Immunology biology.protein Female Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.9096-17 |
| Popis: | Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma. Treatment for multiple myeloma may improve autoimmune autonomic ganglionopathy. |
| Databáze: | OpenAIRE |
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