Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas
| Autor: | Yasuko Yamamoto, Masao Takemura, Seiji Adachi, Makoto Shiraki, Kuniaki Saito, Tsuyoshi Takami, Tamotsu Takeuchi, Naoe Goto, Yuhei Shibata, Koshiro Saito, Kuniaki Yabe, Wakana Yamasuge, Takeshi Hara, Masahito Shimizu, Ginette Serrero, Tatsuhiko Miyazaki, Hisashi Tsurumi, Nobuhiko Nakamura |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Poor prognosis Pathology Clinical Biochemistry Inflammation medicine.disease_cause Biochemistry Gastroenterology Young Adult 03 medical and health sciences Elisa kit Glycosylated protein Progranulins 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans In patient Aged Aged 80 and over business.industry Biochemistry (medical) General Medicine Middle Aged Prognosis medicine.disease Lymphoma Gene Expression Regulation Neoplastic 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis Intercellular Signaling Peptides and Proteins Immunohistochemistry Female Lymphoma Large B-Cell Diffuse medicine.symptom Carcinogenesis business |
| Zdroj: | Clinica Chimica Acta. 473:139-146 |
| ISSN: | 0009-8981 |
| Popis: | GP88 (progranulin; PGRN) is a secreted 88kDa glycosylated protein, with important functions, including inflammation and tumorigenesis. We assessed the significance of GP88 expression in survival outcomes of patients with malignant lymphoma (ML).Serum samples from 254 previously untreated ML patients were examined to measure GP88 concentrations using a sandwich human GP88 ELISA kit. Immunohistochemical analyses were performed to examine GP88 tumor tissue expression.The median serum GP88 concentration of ML patients was 91.3ng/ml, and was significantly higher than that of the control group (median, 57.7ng/ml) (p0.0001). Association between GP88 serum concentrations and overall survival (OS) was examined in patients with diffuse large B cell lymphoma (DLBCL) who had been stratified based on their serum GP88 concentrations. Kaplan Meier survival analysis showed that patients with serum GP88 concentrations of ≤116 and116ng/ml, had 5-y OS rates of 70% and 50%, respectively (p=0.02). The immunohistochemical analyses of GP88 tumor expression revealed that DLBCL patients had lymphoma cells that were positive for GP88.High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL. |
| Databáze: | OpenAIRE |
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