Development of a NovelIn VitroChemosensitivity Assay: Telomerase as a Possible Marker of Tumor Cell Survival
| Autor: | Isabella Faraoni, Mario Turriziani, E. Bonmasssar, Grazia Graziani, L De Vecchis |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Telomerase
Cell Survival Cell Tetrazolium Salts Antineoplastic Agents Cell Count Biology Jurkat cells Jurkat Cells Biomarkers Tumor Tumor Cells Cultured medicine Humans Pharmacology (medical) Coloring Agents Cytotoxicity Antineoplastic Agents Alkylating Tumor marker Ribonucleoprotein Pharmacology Carmustine In vitro Thiazoles Infectious Diseases medicine.anatomical_structure Oncology Immunology Cancer research Chemosensitivity assay |
| Zdroj: | Journal of Chemotherapy. 8:394-398 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.1996.8.5.394 |
| Popis: | Telomerase is a ribonucleoprotein enzyme which is involved in the maintenance of chromosome ends. Telomerase activity (TLMA) is required for cell immortality and can be considered a ubiquitous tumor marker. In this study we describe a new approach for developing in vitro chemosensitivity assays based on the assessment of TLMA in tumors, upon treatment with antineoplastic agents. The results of preliminary studies on in vitro cultured tumor cell lines indicate that TLMA inhibition can be used as a marker of tumor cell killing by anticancer drugs. Therefore the present investigation provides the rational basis for an in vitro chemosensitivity assay based on TLMA evaluation. |
| Databáze: | OpenAIRE |
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