European Gene Mapping Project (EUROGEM): Breakpoint panels for human chromosomes based on the CEPH reference families

Autor:	S. A. COX, J. ATTWOOD, S. P. BRYANT, R. BAINS, S. POVEY, M. REBELLO, M. KAPSETAKI, N. K. MOSCHONAS, K.-H. GRZESCHIK, M. OTTO, M. DIXON, H. E. SUDWORTH, R. F. KOOY, A. WRIGHT, P. TEAGUE, L. TERRENATO, G. VERGNAUD, S. MONFOUILLOUX, J. WEISSENBACH, O. ALIBERT, C. DIB, S. FAURÉ, E. BARKER, N. M. PEARSON, R. H. A. M. VOSSEN, A. GAL, B. MUELLER-MYHSOK, H. M. CANN, N. K. SPURR
Předmět:	Genetics Positional cloning Breakpoint ALLELIC LOSS Chromosome LOCALIZATION Biology Genome MELANOMA KINDREDS REGION Gene mapping RESOLUTION Genetic marker HOMOZYGOUS DELETION HUMAN GENOME BREAST-CANCER Human genome Genotyping Genetics (clinical) CONSORTIUM LINKAGE MAP POSITIONAL CLONING
Zdroj:	Scopus-Elsevier Annals of Human Genetics, 60, 447-486. Wiley
ISSN:	0003-4800
Popis:	Meiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 17, 18, 20 and X were constructed from genotypes from the CEPH reference families. Each recombinant chromosome included has a breakpoint well-supported with reference to defined quantitative criteria. The panels were constructed at both a low-resolution, useful for a first-pass localization, and high-resolution, for a more precise placement. The availability of such panels will reduce the number of genotyping experiments necessary to order new polymorphisms with respect to existing genetic markers. This paper shows only a representative sample of the breakpoints detected. The complete data are available on the World Wide Web (URL http:/(/)www.icnet.uk/axp/hgr/eurogem++ +/HTML/data.html) or by anonymous ftp (ftp.gene.ucl.ac.uk in/pub/eurogem/maps/breakpoints).
Databáze:	OpenAIRE
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