Comorbidities Associated with Granuloma Annulare: A Cross-Sectional, Case-Control Study
| Autor: | Jihad Alhariri, Yevgeniy R. Semenov, Justin Choi, Caroline X. Qin, Kyle A. Williams, Nishadh Sutaria, Shawn G. Kwatra, Youkyung S. Roh, Erik Almazan, Benjamin H. Kaffenberger, Micah Belzberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Disease Article 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Granuloma annulare granulomatous disorders of the skin General Environmental Science business.industry inflammatory skin conditions Medical record lcsh:R Confounding General Engineering Case-control study Odds ratio medicine.disease Confidence interval medical dermatology granuloma annulare 030220 oncology & carcinogenesis Etiology General Earth and Planetary Sciences business |
| Zdroj: | Medicines Volume 7 Issue 9 Medicines, Vol 7, Iss 53, p 53 (2020) |
| ISSN: | 2305-6320 |
| DOI: | 10.3390/medicines7090053 |
| Popis: | Background: Granuloma annulare (GA) is a cutaneous granulomatous disorder of unknown etiology. There are conflicting data on the association between GA and multiple systemic conditions. As a result, we aimed to clarify the reported associations between GA and systemic conditions. Methods: A retrospective, cross-sectional, case-control study was performed in which the medical records of biopsy-confirmed GA patients ≥18 years of age, who presented to the Johns Hopkins Hospital System between 1 January 2009 and 1 June 2019, were reviewed. GA patients were compared to controls matched for age, race, and sex. Results: After adjusting for confounders, GA patients (n = 82) had higher odds of concurrent type II diabetes (odds ratio (OR) = 5.27 95% confidence interval (CI), 1.73–16.07 p < 0.01), non-migraine headache (OR = 8.70 95% CI, 1.61–46.88 p = 0.01), and a positive smoking history (OR = 1.93 95% CI, 1.10–3.38 p = 0.02) compared to controls (n = 164). Among GA patients, women were more likely to have ophthalmic conditions (p = 0.04), and men were more likely to have cardiovascular disease (p < 0.01) and type II diabetes (p = 0.05). No differences in systemic condition associations were observed among GA subtypes. Conclusions: Our results support the reported association between GA and type II diabetes. Furthermore, our findings indicate that GA may be associated with cigarette smoking and non-migraine headache disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|