Proton MRS Can Determine the Pathology of Human Cancers with a High Level of Accuracy
| Autor: | Cynthia L. Lean, Carolyn E. Mountford, Sinead Doran, Peter Russell |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Cellular metabolism medicine.diagnostic_test Chemistry Magnetic resonance imaging General Medicine General Chemistry Nuclear magnetic resonance spectroscopy Middle Aged Magnetic Resonance Imaging Nuclear magnetic resonance Neoplasms Cancer cell medicine Humans Female Protons Proton mrs Relevant information Aged |
| Zdroj: | Chemical Reviews. 104:3677-3704 |
| ISSN: | 1520-6890 0009-2665 |
| DOI: | 10.1021/cr030410g |
| Popis: | The first report of a high-resolution proton (1H) magnetic resonance spectrum from intact viable cancer cells was made by Block and colleagues in 1973,1 who suggested 1H magnetic resonance spectroscopy (MRS) might lead to pathologically relevant information. However, at this time 1H was not the favored nucleus since adequate water suppression was difficult and small resonances were swamped by a much larger water signal. Carbon-13 (13C) MRS2 and phosphorus-31 (31P MRS3 were the preferred methods for monitoring cellular metabolism and intact viable cells and organs... |
| Databáze: | OpenAIRE |
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