Synthesis of a Series of Diaminoindoles
| Autor: | Claire J. MacKenzie, Ian H. Gilbert, James Martin |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of Organic Chemistry |
| ISSN: | 1520-6904 |
| Popis: | A selection of 3,4-diaminoindoles were required for a recent drug discovery project. To this end, a 10-step synthesis was developed from 4-nitroindole. This synthesis was subsequently adapted and used to synthesize 3,5-; 3,6-; and 3,7-diaminoindoles from the corresponding 5-, 6-, or 7-nitroindole. These novel intermediates feature orthogonal protecting groups that allow them to be further diversified. This is the first reported synthesis of these types of compounds. |
| Databáze: | OpenAIRE |
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