Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing?
| Autor: | Joost B. L. Hoekstra, Th.B. Twickler, J. H. von der Thüsen, Anne Q. Reuwer, John J.P. Kastelein, Benoit J. Arsenault, K.L. Rensing |
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| Přispěvatelé: | Experimental Vascular Medicine, Other departments, Amsterdam Cardiovascular Sciences, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Vascular Medicine |
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Basic science Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Type 2 diabetes Diabetes Complications Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Insulin Intensive care medicine education Veterans Affairs Macrovascular disease education.field_of_study Clinical Trials as Topic business.industry Middle Aged medicine.disease Clinical trial Diabetes Mellitus Type 2 Cardiovascular Diseases Female Human medicine business |
| Zdroj: | Diabetes, obesity & metabolism, 13(12), 1073-1087. Wiley-Blackwell Diabetes obesity and metabolism |
| ISSN: | 1463-1326 1462-8902 |
| Popis: | Despite improvement of microvascular outcomes as a consequence of optimal glucose control in patients with type 2 diabetes, prevention of macrovascular complications is still a major challenge. Of interest, large-scale intervention studies (Action to Control Cardiovascular Risk in Diabetes, Action in Diabetes and Vascular Disease-Preterax and Diamicron Modified Release Controlled Evaluation and Veterans Affairs Diabetes Trial) comparing standard therapy versus more intensive glucose-lowering therapy failed to report beneficial impacts on macrovascular outcomes. Consequently, it is currently under debate whether the high doses of exogenous insulin that were administered in these trials to achieve strict target glucose levels could be responsible for these unexpected outcomes. Additionally, a potential role for plasma insulin levels in predicting macrovascular outcomes has emerged in patients with or without type 2 diabetes. These observations, combined with evidence from in vitro and animal experiments, suggest that insulin might have intrinsic atherogenic effects. In this review, we summarize clinical trials, population-based studies as well as data emerging from basic science experiments that point towards the hypothesis that the administration of high insulin doses might not be beneficial in patients with type 2 diabetes and established macrovascular disease. |
| Databáze: | OpenAIRE |
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