A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gao
| Autor: | Livio Oboti, Frank Zufall, Pablo Chamero, Eric Jacobi, Trese Leinders-Zufall, Matthieu Keller, Anabel Pérez-Gómez, Lutz Birnbaumer |
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| Přispěvatelé: | Saarland University [Saarbrücken], Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Department of Physiology, Center for Neuroscience Research, Children's National Health System, Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), German Center for Neurodegenerative Diseases, Laboratory of Neurobiology, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Deutsche Forschungsgemeinschaft CH 920/2-1 SFB 894/A17 SFB 894/A16, Intramural Research Program of the NIH Z01 ES-101643, Volkswagen Foundation, French Agence Nationale de la Recherche (Pherosex grant), DFG-funded International Graduate Program GK1326, ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Vomeronasal organ Plant Science drug effects [Choice Behavior] Choice Behavior lordosis Pheromones Mice Sexual Behavior Animal Genes Reporter comportement sexuel Sexual Maturation Mating Gonadal Steroid Hormones mate recognition ComputingMilieux_MISCELLANEOUS bruce effect estrus induction gao signaling puberty acceleration reproduction Reproduction Lordosis behavior 3. Good health [SDV] Life Sciences [q-bio] Smell Pheromone General Agricultural and Biological Sciences Gαo signaling medicine.medical_specialty [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] Posture Bruce effect General Biochemistry Genetics and Molecular Biology performance de reproduction Ciencias Biológicas drug effects [Central Nervous System] système olfactif [INFO]Computer Science [cs] Ecology Evolution Behavior and Systematics Estrous cycle signal chimique Reproductive success drug effects [Sexual Maturation] drug effects [Smell] protéine g Mice Inbred C57BL Endocrinology metabolism [Green Fluorescent Proteins] drug effects [Reproduction] Commentary pathology [Central Nervous System] Gene Deletion Developmental Biology Central Nervous System Physiology metabolism [Gonadal Steroid Hormones] [SDV]Life Sciences [q-bio] souris comportement animal purl.org/becyt/ford/1 [https] 5. Gender equality Structural Biology metabolism [GTP-Binding Proteins] drug effects [Estrous Cycle] Agricultural and Biological Sciences(all) drug effects [Sexual Behavior Animal] Sex pheromone metabolism [Central Nervous System] Lordosis Female pathology [Ovary] CIENCIAS NATURALES Y EXACTAS Biotechnology Autre (Sciences du Vivant) odeur sexuelle Otras Ciencias Biológicas Green Fluorescent Proteins Estrous Cycle hormone sexuelle [INFO] Computer Science [cs] Biology femelle GTP-Binding Proteins Internal medicine medicine Animals ddc:610 purl.org/becyt/ford/1.6 [https] Biochemistry Genetics and Molecular Biology(all) Ovary Puberty acceleration Estrus induction Cell Biology pharmacology [Pheromones] Mate recognition |
| Zdroj: | Chemical Senses 24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO) 24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France BMC Biology BMC Biology, BioMed Central, 2014, 12 (1), pp.1-17. ⟨10.1186/1741-7007-12-31⟩ BMC Biology 1 (12), 1-17. (2014) Publons BMC biology 12(1), 31 (2014). doi:10.1186/1741-7007-12-31 CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1741-7007 |
| Popis: | Optimal reproductive fitness is essential for the biological success and survival of species. The vomeronasal organ is strongly implicated in the display of sexual and reproductive behaviors in female mice, yet the roles that apical and basal vomeronasal neuron populations play in controlling these gender-specific behaviors remain largely unclear. Results To dissect the neural pathways underlying these functions, we genetically inactivated the basal vomeronasal organ layer using conditional, cell-specific ablation of the G protein Gαo. Female mice mutant for Gαo show severe alterations in sexual and reproductive behaviors, timing of puberty onset, and estrous cycle. These mutant mice are insensitive to reproductive facilitation stimulated by male pheromones that accelerate puberty and induce ovulation. Gαo-mutant females exhibit a striking reduction in sexual receptivity or lordosis behavior to males, but gender discrimination seems to be intact. These mice also show a loss in male scent preference, which requires a learned association for volatile olfactory signals with other nonvolatile ownership signals that are contained in the high molecular weight fraction of male urine. Thus, Gαo impacts on both instinctive and learned social responses to pheromones. Conclusions These results highlight that sensory neurons of the Gαo-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice. Fil: Oboti, Livio. University of Saarland School of Medicine. Hamburgo; Alemania. Center for Neuroscience Research. Washington; Estados Unidos Fil: Pérez Gómez, Anabel. University of Saarland School of Medicine. Hamburgo; Alemania Fil: Keller, Matthieu. Universite de Tours; Francia Fil: Jacobi, Eric. University of Saarland School of Medicine. Hamburgo; Alemania. Deutsches Zentrum für Neurodegenerative Erkrankunge. Heidelberg; Armenia Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institute of Environmental Health Sciences; Estados Unidos Fil: Leinders Zufall, Trese. University of Saarland School of Medicine. Hamburgo; Alemania Fil: Zufall, Frank. University of Saarland School of Medicine. Hamburgo; Alemania Fil: Chamero, Pablo. University of Saarland School of Medicine. Hamburgo; Alemania |
| Databáze: | OpenAIRE |
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