Efficient synthesis of a new pipecolic acid analogue with a bicyclic structure
| Autor: | Carlos Cativiela, Diego Casabona |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Constrained amino acid
chemistry.chemical_classification Bicyclic molecule Organic Chemistry Biochemistry Proline analogue Quaternary amino acid Amino acid chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Chemoselective reduction Organic chemistry 2 5-Ethanepipecolic acid Pipecolic acid |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2006.08.006 |
| Popis: | 5 pages, 3 figures, scheme 1. This report describes the synthesis of 2-azabicyclo[2.2.2]octane-1-carboxylic acid, a constrained pipecolic acid analogue. The route gives a very good total yield starting from cheap and readily available compounds and uses very easy reactions. Financial support from Ministerio de Educación y Ciencia–FEDER (project CTQ2004-5358) and Diputación General de Aragón (project PIP206/2005 and group E40) is gratefully acknowledged. D.C. thanks CSIC for an I3P grant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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