Urinary albumin excretion rate and puberty in non-diabetic children and adolescents
| Autor: | K. Mevold, Knut Dahl-Jørgensen, Hans-Jacob Bangstad, P. Kjaersgaard, Hanssen Kf |
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| Rok vydání: | 1993 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Urinary albumin Adolescent Urology Renal function Urine Diabetic nephropathy Excretion chemistry.chemical_compound Reference Values Internal medicine Albumins Medicine Albuminuria Humans Child Creatinine business.industry Puberty Albumin General Medicine medicine.disease Endocrinology chemistry Pediatrics Perinatology and Child Health Microalbuminuria Female medicine.symptom business Non diabetic |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 82(10) |
| ISSN: | 0803-5253 |
| Popis: | Slightly elevated urinary albumin excretion rate (microalbuminuria) is a marker of early diabetic nephropathy, but it is unclear if the established definition of microalbuminuria (20-200 micrograms/min) is correct for children and adolescents. We investigated the albumin excretion rate, albumin/creatinine ratio and urinary albumin concentration in 150 healthy schoolchildren and adolescents to (a) obtain a reference value for albumin excretion rate, (b) relate albumin excretion to pubertal stages and (c) evaluate albumin/creatinine ratio and morning albumin concentration as screening methods for elevated albumin excretion rate. Albumin concentration was measured by immunoturbidimetry in timed overnight urine samples. The albumin excretion showed a skewed distribution (geometric mean 3.2 micrograms/min, 95 percentile 15.1 micrograms/min). In girls, a peak in the albumin excretion rate was found at the pubertal stage 4 (Tanner) and in boys at stage 5. Albumin/creatinine ratio of 2.5 mg/mmol as a screening level for elevated albumin excretion (15 micrograms/min) showed a high positive (0.88) and negative (0.99) predictive value. |
| Databáze: | OpenAIRE |
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