Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed
| Autor: | M. Redondeiro, A. Albuquerque, J.A. Neves, J.M. Martins, José L Tirapicos, Maria do Rosário Félix, Marta Laranjo, A.B. Freitas |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Swine Down-Regulation Biology Breeding 03 medical and health sciences chemistry.chemical_compound Betaine Internal medicine Gene expression medicine Lipolysis Animals Obesity Muscle Skeletal chemistry.chemical_classification Cholesterol Fatty Acids 0402 animal and dairy science Lipid metabolism 04 agricultural and veterinary sciences Lipid Metabolism 040201 dairy & animal science Animal Feed Diet Up-Regulation 030104 developmental biology Endocrinology chemistry Adipose Tissue Lipogenesis LDL receptor Dietary Supplements lipids (amino acids peptides and proteins) Food Science Polyunsaturated fatty acid Transcription Factors |
| Zdroj: | Meat science. 124 |
| ISSN: | 1873-4138 |
| Popis: | This study evaluates the effects of betaine supplementation (1gkg-1 for 20weeks) on the regulation of genes involved in lipid and cholesterol metabolism of Longissimus lumborum and Biceps femoris from obese Alentejano pigs. Betaine supplementation led to an increase in total cholesterol in both muscles, complementing results previously published indicating a significant increase on the intramuscular lipid content. The expression of twelve genes involved in lipogenesis, lipolysis/FA oxidation, FA transport, and cholesterol metabolism, as well as two transcription factors were also evaluated. Genes related to lipid and cholesterol synthesis plus FA transport were consistently up-regulated in both muscles of betaine fed pigs. On the other hand, genes related to lipolysis/FA oxidation were not affected or down-regulated by betaine supplementation. Our data suggest that the underlying mechanism regulating IMF and cholesterol accumulation in Alentejano pigs supplemented with betaine is associated with the up-regulation of genes involved in lipid synthesis, FA transport, and cholesterol synthesis. |
| Databáze: | OpenAIRE |
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