Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation
| Autor: | Tiesheng Shi, Jingran Dong, Hongwu Tian, Lars Ivar Elding, Changying Song |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Organoplatinum Compounds 010405 organic chemistry Kinetics Antineoplastic Agents Hydrogen-Ion Concentration 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Inorganic Chemistry Dissociation constant Reduction (complexity) Ormaplatin Reaction rate constant chemistry Thiol Ph range Molecule Prodrugs Sulfhydryl Compounds Oxidation-Reduction |
| Zdroj: | Dalton Transactions. 47:5548-5552 |
| ISSN: | 1477-9234 1477-9226 |
| Popis: | Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(iv) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log kRS- and the thiol dissociation constants pKRSH is disclosed: log kRS- = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS- denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin. |
| Databáze: | OpenAIRE |
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