Chemoenzymatic routes to enantiomerically pure 2-azatyrosine and 2-, 3- and 4-pyridylalanine derivatives
| Autor: | Patrick Meffre, Valérie Rolland, Amer Moussa, Jean Martinez |
|---|---|
| Přispěvatelé: | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Nîmes (UNIMES) |
| Rok vydání: | 2011 |
| Předmět: |
Pseudomonas aeruginosa elastase
Stereochemistry Clinical Biochemistry Peptide Stereoisomerism 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Structure-Activity Relationship Azatyrosine medicine Chymotrypsin Structure–activity relationship Enzyme Inhibitors chemistry.chemical_classification Alanine Molecular Structure [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Pseudomonas aeruginosa Organic Chemistry Elastase 0104 chemical sciences 3. Good health Kinetics Enzyme chemistry Heterocyclic a-amino acids |
| Zdroj: | Amino Acids Amino Acids, Springer Verlag, 2012, 42, pp.1339-1348. ⟨10.1007/s00726-010-0829-3⟩ |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s00726-010-0829-3 |
| Popis: | International audience; Enantiomerically pure 2-, 3- or 4-pyridylalanine (pya) and 2-azatyrosine (azatyr) are known to present various biological activities. After incorporation into appropriate peptide sequences, these heterocyclic non natural a-amino acids could behave as new substrates or inhibitors of elastase from Pseudomonas aeruginosa.This enzyme is known to be involved in nosocomial infections and infections related to the cystic fibrosis disease. New efficient chemoenzymatic preparations of those compounds using a-chymotrypsin (a-CT) are presented. |
| Databáze: | OpenAIRE |
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