Differentiation Between Multiple System Atrophy and Other Spinocerebellar Degenerations Using Diffusion Kurtosis Imaging
| Autor: | Kenji Ito, Makoto Sasaki, Kunihiro Yoshioka, Futoshi Mori, Chigumi Ohtsuka, Tsuyoshi Matsuda, Yasuo Terayama, Tetsuya Maeda, Suguru Yokosawa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Cerebellum Ataxia 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance parasitic diseases Fractional anisotropy Image Processing Computer-Assisted medicine Middle cerebellar peduncle Humans Radiology Nuclear Medicine and imaging Diffusion Kurtosis Imaging Aged Spinocerebellar Degenerations Aged 80 and over Cerebellar ataxia business.industry Middle Aged Multiple System Atrophy medicine.disease nervous system diseases Diffusion Magnetic Resonance Imaging medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Spinocerebellar ataxia Female medicine.symptom business |
| Zdroj: | Academic Radiology. 26:e333-e339 |
| ISSN: | 1076-6332 |
| Popis: | Differentiation between multiple system atrophy (MSA) and other spinocerebellar degenerations showing cerebellar ataxia is often difficult. Hence, we investigated whether magnetic resonance diffusion kurtosis imaging (DKI) could detect pathological changes that occur in these patients and be used for differential diagnosis.Thirty-six subjects (12 patients with MSA accompanied by predominant cerebellar ataxia [MSA-C], 10 patients with spinocerebellar ataxias [SCAs] or sporadic adult-onset ataxia of unknown etiology [SAOA], and 14 healthy controls) were examined using 1.5- or 3-T magnetic resonance scanners. From the DKI data, the mean kurtosis, fractional anisotropy, and mean diffusivity values of the pontine crossing tract (PCT), middle cerebellar peduncle, and cerebellum were automatically measured, and the ratios against the values of the corpus callosum were calculated.We found significant decreases in mean kurtosis and fractional anisotropy ratios in the PCT and middle cerebellar peduncle, and a significant increase in the mean diffusivity ratio in the PCT in the MSA-C group, as compared with the SCA/SAOA and control groups (p0.027-0.001). Among these metrics, there were no significant differences in the diagnostic performance. By contrast, the ratios in the cerebellum showed no significant differences between the MSA-C and SCA/SAOA groups but were significantly altered when compared with the controls (p0.001).Quantitative DKI analyses can be used to differentiate between patients with MSA-C and those with SCA/SAOA. |
| Databáze: | OpenAIRE |
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