Structural Brain Network Correlated with Reading Impairment in Alzheimer's Disease
| Autor: | Miho Ota, Shinji Higashi, Yuko Koshibe, Tetsuaki Arai, Masashi Tamura, Eriko Tsukada, Takumi Takahashi, Kiyotaka Nemoto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Kanji Cognitive Neuroscience media_common.quotation_subject Disease Audiology 03 medical and health sciences 0302 clinical medicine Betweenness centrality Japan Alzheimer Disease Reading (process) Aphasia medicine Connectome Dementia Humans media_common Aged Brain network Language Tests 030214 geriatrics medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Reading Female Geriatrics and Gerontology medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Dementia and geriatric cognitive disorders. 49(3) |
| ISSN: | 1421-9824 |
| Popis: | Aim: Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and leads to dementia. AD is characterized by progressive declines in memory and, as the disease progresses, language dysfunction. Although it has been reported that AD patients show progressive aphasia, no study has examined the relationship between language functions estimated by the Standard Language Test for Aphasia (SLTA) and brain network connectivity in Japanese AD patients. If present, such a relationship would be of particular interest because Japanese speakers are accustomed to mingling ideography and phonography. Methods: 22 Japanese patients with AD who underwent 1.5-tesla MRI scan and SLTA, the scale for speech and reading impairment, participated in this study. We computed brain network connectivity metrics such as degree, betweenness centrality, and clustering coefficient, and estimated their relationships with the subscores of SLTA. Results: There was a significant negative correlation between the score for “reading aloud Kanji words” and the clustering coefficient in the left inferior temporal region, bilateral hippocampal regions, and right parietotemporal region. We also found a significant negative correlation between the score for “auditory comprehension of words” and the clustering coefficient in the left prefrontal region. No significant relationship was found between the other SLTA scores and the network metrics. Conclusions: Our data suggest relationships between reading impairments and regional brain network connectivity in Japanese patients with AD. The brain connectome may provide adjunct biological information that could improve our understanding of reading impairment. |
| Databáze: | OpenAIRE |
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