Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation
| Autor: | Christopher Colling, Lucile E. Wrenshall, Elizabeth Lyden, Jennifer L. Larsen, R. Brian Stevens, James T. Lane, Lynn Mack-Shipman |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Urinary system Urology Pancreas transplantation Organ transplantation Body Mass Index Diabetes Complications Sex Factors Diabetes mellitus medicine Humans Immunosuppression Therapy Transplantation business.industry Graft Survival Age Factors Immunosuppression Middle Aged medicine.disease Kidney Transplantation Surgery Survival Rate surgical procedures operative medicine.anatomical_structure Treatment Outcome Female Pancreas Transplantation Pancreas business Body mass index Follow-Up Studies |
| Zdroj: | Clinical transplantation. 19(2) |
| ISSN: | 0902-0063 |
| Popis: | Background: Gender differences in graft survival has been reported after some types of organ transplantation, but not after pancreas transplantation. This study compares graft survival between women and men after simultaneous pancreas–kidney transplantation (SPK). Methods: All first time SPK (n = 163) transplants (109 M/54 F) performed between 1989 and 2000 at University of Nebraska Medical Center, where data was available, were analyzed for overall graft and patient survival. Graft failure was then subdivided into early ( 6 months), and compared between women and men. Results: The 5-yr pancreas and kidney graft survival rates for all SPK recipients was 86% [95% confidence interval (CI) = 81–92%] and 87% (95% CI = 82–93%), respectively. While overall pancreas graft survival in women was similar to men (p = 0.16), early pancreas graft failure was greater in women than men (p = 0.010) with no one cause for failure predominant. There was no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients. The gender difference was unexplained by differences in age, immunosuppression, body mass index (BMI), or diabetes duration between women and men. Conclusions: This is the first report of a gender difference in pancreas graft survival after SPK with greater early ( |
| Databáze: | OpenAIRE |
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