The effects of walnut supplementation on hippocampal NMDA receptor subunits NR2A and NR2B of rats
| Autor: | Recep Sutcu, Nigar Yilmaz, Fatih Gultekin, Hicran Hicyilmaz, Hüseyin Vural, Namik Delibas |
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| Přispěvatelé: | MÜ, Tıp Fakültesi, Temel Tıp Bilimleri, Yılmaz, Nigar |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Period (gene) Blotting Western Medicine (miscellaneous) Down-Regulation Dietary factors Juglans Nerve Tissue Proteins Hippocampal formation Biology Receptors N-Methyl-D-Aspartate Hippocampus Lipid peroxidation Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Random Allocation Walnut Diet 0302 clinical medicine Functional Food Internal medicine medicine Hippocampus (mythology) Animals Nuts Cognitive Dysfunction Receptor Neurons Nutrition and Dietetics General Neuroscience General Medicine Thiobarbiturates Neuroprotection Up-Regulation Blot NMDAR 030104 developmental biology Endocrinology chemistry nervous system NMDA receptor Lipid Peroxidation 030217 neurology & neurosurgery Biomarkers |
| Popis: | WOS: 000399671500006 PubMed ID: 25521238 Objectives: Walnuts contain numerous selected dietary factors that have an impact on brain functions, especially learning and memory formation in the hippocampus. Hippocampal N-methyl D-aspartate receptors (NMDARs) are involved in the formation of cognitive functions. In this study, we aimed to investigate the molecular effects of walnut supplementation on the hippocampal expressions of NMDARs involved in cognitive functions and lipid peroxidation levels in rats. Methods: The male Sprague-Dawley rats (6 months old, n = 24) were fed with a walnut-supplemented diet (6% walnut diet, n = 12) and a control diet (rat food, n = 12) as ad libitum for 8 weeks. At the end of this period, NMDAR subunits NR2A and NR2B in the hippocampi were assayed by western blotting. Lipid peroxidation levels were measured using the thiobarbituric acid. Results: The expression of NR2A and NR2B was elevated in the walnut-supplemented rats compared with the control group (P < 0.05). In addition, the levels of lipid peroxidation in the walnut-supplemented group were significantly decreased compared with the control group. Discussion: We suggested that walnut supplementation may have protective effects against the decline of cognitive functions by regulating NMDAR and lipid peroxidation levels in the hippocampus. The study provides evidence that selected dietary factors (polyunsaturated fatty acids, melatonin, vitamin E, and flavonoids) within walnut may help to trigger hippocampal neuronal signal transduction for the formation of learning and memory. |
| Databáze: | OpenAIRE |
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