Crystalline and Amorphous Phases of a New Drug
| Autor: | Vittorio Berbenni, Marco Villa, Amedeo Marini, Giovanna Bruni, Franco Sartor, Chiara Milanese |
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| Rok vydání: | 2010 |
| Předmět: |
Settore CHIM/03 - Chimica Generale e Inorganica
TMDSC Chemistry Stereochemistry Thermodynamics Condensed Matter Physics law.invention Amorphous solid DSC polymorphism Differential scanning calorimetry Polymorphism (materials science) law double melting enantiotropy Microemulsion Soft matter Physical and Theoretical Chemistry Crystallization Thermal analysis Glass transition |
| Zdroj: | info:cnr-pdr/source/autori:G. Bruni, C. Milanese, V. Berbenni, F. Sartor, M. Villa, A. Marini/titolo:Crystalline and Amorphous Phases of a New Drug/doi:/rivista:/anno:2010/pagina_da:297/pagina_a:303/intervallo_pagine:297–303/volume:102 |
| Popis: | The thermodynamic properties of a new antidepressant drug are studied from room temperature to 200 °C. In this range, the sample neither decompose, nor has a significant reactivity with water. When slowly heating a “fresh” sample, we may observe the following phenomena (in the order): melting of a form (F1, ~170 °C), crystallization of a structurally different form (F2), and melting of F2 (~180 °C). In no circumstances, the direct transition from F1 to F2 can be observed. On the other hand, F2 reverts to F1 upon cooling below ~130 °C. A glassy phase is formed upon cooling from above 180 °C, as confirmed by X-ray analysis and the appearance of a glass transition when reheating. The “reversible” (e.g., melting) and “irreversible” (e.g., glass formation) contributions to the measured enthalpies are estimated with temperature-modulated DSC measurements, resulting into a consistent description of thermodynamics of the forms, their melting and their kinetics of transformation. |
| Databáze: | OpenAIRE |
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