Increased prolyl endopeptidase activity in human neoplasia
| Autor: | Carmen Etxezarraga, Leire Andrés, Gorka Larrinaga, Francisco Santaolalla, Adolfo Varona, José I. López, Itxaro Perez, Jon Irazusta, Lorena Blanco, Aitor Zabala |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology education Clinical Biochemistry Biology Biochemistry Cellular and Molecular Neuroscience Endocrinology Testicular Neoplasms Prolyl endopeptidase Internal medicine medicine Humans Thyroid Neoplasms Laryngeal Neoplasms Aged Aged 80 and over chemistry.chemical_classification Kidney Serine Endopeptidases Thyroid Cancer Biological activity Middle Aged medicine.disease Head and neck squamous-cell carcinoma Kidney Neoplasms Clear cell renal cell carcinoma Enzyme medicine.anatomical_structure chemistry cardiovascular system Female Mouth Neoplasms Colorectal Neoplasms Prolyl Oligopeptidases circulatory and respiratory physiology medicine.drug |
| Zdroj: | Regulatory Peptides. 163:102-106 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2010.03.012 |
| Popis: | Prolyl endopeptidase (EC 3.4.21.26) (PEP) is a serine peptidase that converts several biologically active peptides. This enzyme has been linked to several neurological, digestive, cardiovascular and infectous disorders. However, little is known about its involvement in neoplastic processes. This study analyzes fluorimetrically cytosolic and membrane-bound PEP activity in a large series (n=122) of normal and neoplastic tissues from the kidney, colon, oral cavity, larynx, thyroid gland and testis. Cytosolic PEP activity significantly increased in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma. Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps. These data suggest the involvement of PEP in some mechanisms that underlie neoplastic processes. |
| Databáze: | OpenAIRE |
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