Bacterial infections and patterns of antibiotic use in patients with COVID-19
| Autor: | Janani Rangaswami, Kevin Bryan Lo, Fahad Gul, Jeri Albano, Ruchika Bhargav, Eric Peterson, Ammaar Wattoo, Robert DeJoy, Jerald Pelayo, Zurab Azmaiparashvili, Gabriel Patarroyo-Aponte, Alvaro Goncalves Mendes Neto, Grace Salacup |
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| Rok vydání: | 2020 |
| Předmět: |
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medicine.medical_specialty medicine.drug_class Antibiotics pandemics Logistic regression SARS‐CoV‐2 antibiotic use 03 medical and health sciences 0302 clinical medicine Virology Intensive care Internal medicine medicine Humans 030212 general & internal medicine Research Articles Aged Genitourinary system business.industry Coinfection Mortality rate COVID-19 Bacterial Infections Middle Aged medicine.disease Anti-Bacterial Agents Hospitalization Intensive Care Units Infectious Diseases coinfections inflammation Viral pneumonia Concomitant 030211 gastroenterology & hepatology Female business Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 |
| Popis: | Introduction Bacterial coinfection is associated with poor outcomes in patients with viral pneumonia, but data on its role in the mortality of patients with COVID‐19 is limited. Methods This is a single‐center retrospective analysis of 242 patients with confirmed coronavirus disease 2019 (COVID‐19) admitted to both intensive care and non‐intensive care settings. Bacterial coinfection was determined by the presence of characteristic clinical features and positive culture results. Multivariable logistic regression was used to analyze the association of concomitant bacterial infection with inpatient death after adjusting for demographic factors and comorbidities. Antibiotic use pattern was also determined. Results Bacterial coinfection was detected in 46 (19%) patients. Genitourinary source was the most frequent, representing 57% of all coinfections. The overall mortality rate was 21%. Concomitant bacterial infections were independently associated with increased inpatient mortality (OR: 5.838; 95% CI: 2.647‐12.876). Patients with bacterial coinfection were relatively older (71.35±11.20 vs. 64.78±15.23; p 0.006%). 67% of patients received antibiotic therapy, yet 72% did not have an obvious source of bacterial infection. There was a significantly higher rate of inpatient mortality in patients who received antibiotics compared to those who did not (30% vs. 5%; p |
| Databáze: | OpenAIRE |
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