Noncoding RNAs Set the Stage for RNA Polymerase II Transcription
| Autor: | Shona Murphy, Cécilia Studniarek, Sylvain Egloff |
|---|---|
| Přispěvatelé: | Laboratoire de biologie moléculaire eucaryote (LBME), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Sir William Dunn School of Pathology [Oxford], University of Oxford [Oxford] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
RNA
Untranslated Transcription Genetic [SDV]Life Sciences [q-bio] RNA polymerase II Transcription initiation 03 medical and health sciences 0302 clinical medicine Transcription (biology) 7SK RNA Gene expression Genetics Animals Humans RNA Messenger RNA Processing Post-Transcriptional Gene ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Rna processing biology Chromatin Cell biology Gene Expression Regulation biology.protein RNA Polymerase II 030217 neurology & neurosurgery |
| Zdroj: | Trends in Genetics Trends in Genetics, Elsevier, 2020, ⟨10.1016/j.tig.2020.09.013⟩ Trends in Genetics, Elsevier, 2021, 37 (3), pp.279-291. ⟨10.1016/j.tig.2020.09.013⟩ |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/j.tig.2020.09.013⟩ |
| Popis: | International audience; Effective synthesis of mammalian messenger (m)RNAs depends on many factors that together direct RNA polymerase II (pol II) through the different stages of the transcription cycle and ensure efficient cotranscriptional processing of mRNAs. In addition to the many proteins involved in transcription initiation, elongation, and termination, several noncoding (nc)RNAs also function as global transcriptional regulators. Understanding the mode of action of these non-protein regulators has been an intense area of research in recent years. Here, we describe how these ncRNAs influence key regulatory steps of the transcription process, to affect large numbers of genes. Through direct association with pol II or by modulating the activity of transcription or RNA processing factors, these regulatory RNAs perform critical roles in gene expression. |
| Databáze: | OpenAIRE |
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