A retrospective study of patients with systemic lupus erythematosus combined with Pneumocystis jiroveci pneumonia treated with caspofungin and trimethoprim/sulfamethoxazole
| Autor: | Sheng-Quan Tong, Xue-Ming Liu, Qian Wang, Nan-Fang Chen, Zhi-Guo Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Observational Study Pneumocystis carinii Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacotherapy Anti-Infective Agents Pneumocystis jiroveci pneumonia systemic lupus erythematosus Caspofungin immune system diseases Internal medicine Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Lupus Erythematosus Systemic 030212 general & internal medicine skin and connective tissue diseases Retrospective Studies Lupus erythematosus business.industry Pneumonia Pneumocystis Sulfamethoxazole Retrospective cohort study General Medicine Middle Aged medicine.disease Trimethoprim Pneumonia Treatment Outcome chemistry trimethoprim/sulfamethoxazole 030220 oncology & carcinogenesis Drug Therapy Combination Female business CD4+T cell count Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Systemic lupus erythematosus (SLE) complicated with Pneumocystis jiroveci pneumonia (PCP) is a clinical complex with unsatisfying treatment efficacy and poor prognosis which is difficult to be diagnosed at early stage. The present study aimed to investigate the clinical features of SLE with PCP, recognize the early onset indicating factors, and evaluate the treatment efficacy of combined caspofungin and trimethoprim/sulfamethoxazole (coSMZ). We reviewed data of 9 patients admitted with SLE-PCP and treated with caspofungin combined with coSMZ at Tangshan Gongren Hospital from January 2013 to December 2017. Patients’ clinical manifestation and laboratory data [leucocyte, lymphocyte, cluster of differentiation 4 (CD4)+T cell, lactate dehydrogenase (LDH), blood gas, etc] were compared before and after treatments. And the early onset factors of SLE-PCP, treatment efficacy of combined caspofungin and CoSMZ were analyzed. Among these 9 patients, 8 patients suffered renal impairment, and all of them had been taking prednisone in the past 3 months at an average dose of 29.4 ± 13.6 mg/day. In addition, they had taken at least one kind of immunosuppressants. Laboratory data (leucocyte, lymphocyte, CD4+T cell, PaO2, LDH) were remarkably abnormal at hospital admission, but they were improved significantly after 2 weeks of treatment, which is also statistically significant (P |
| Databáze: | OpenAIRE |
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