Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode
| Autor: | Chi K. Li, Frankie W.T. Cheng, Paul K.S. Chan, Martin C.W. Chan, Alex Wing Kwan Leung, Ann H. Wong, Kin Ho Sze |
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| Rok vydání: | 2017 |
| Předmět: |
Hepatitis B virus
HBsAg Genotype Immunoglobulins Mothers medicine.disease_cause Antiviral Agents 03 medical and health sciences 0302 clinical medicine Risk Factors Virology Disease Transmission Infectious medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Hepatitis Hepatitis B Surface Antigens Umbilical Cord Blood Transplantation business.industry Transmission (medicine) Vaccination Infant virus diseases Hepatitis B medicine.disease digestive system diseases Transplantation Infectious Diseases Female 030211 gastroenterology & hepatology business Stem Cell Transplantation 030215 immunology |
| Zdroj: | Journal of Medical Virology. 89:1882-1884 |
| ISSN: | 0146-6615 |
| DOI: | 10.1002/jmv.24835 |
| Popis: | A 22 month old child with thalassaemia major received unrelated umbilical cord blood transplantation. She was born to mother of HBsAg carrier and received hepatitis B immunoglobulin at birth and hepatitis B vaccination. She was HBsAg negative and anti-HBs positive before transplantation. After transplant, she was taken care by her mother and found to be HBsAg positive at 2 year post-transplant. Genotyping of the mother's and child's HBV status confirmed to be of same genotype and demonstrated horizontal transmission in post-transplant setting. Passive immunization of HBV may be considered in early post-transplant phase to prevent horizontal transmission of HBV, and antiviral treatment of the carer should be offered to prevent transmission of infection to immunocompromised child. |
| Databáze: | OpenAIRE |
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