Network-wide abnormalities explain memory variability in hippocampal amnesia
| Autor: | Adriana Roca-Fernandez, Georgios P. D. Argyropoulos, Oana Gurau, Carmen Lage-Martinez, Christopher C Butler, Clare Loane, Sarosh R. Irani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Life Sciences & Biomedicine - Other Topics Male hippocampus Hippocampus Hippocampal formation 0601 Biochemistry and Cell Biology Cohort Studies memory 0302 clinical medicine Thalamus amnesia Cortex (anatomy) Biology (General) RESTING-STATE FMRI General Neuroscience 05 social sciences Limbic encephalitis General Medicine FUNCTIONAL CONNECTIVITY Middle Aged Magnetic Resonance Imaging Hippocampal atrophy ALZHEIMERS-DISEASE medicine.anatomical_structure VOXEL-BASED MORPHOMETRY Hippocampal volume Medicine Female medicine.symptom Hippocampal system Life Sciences & Biomedicine Research Article MRI Human Adult Adolescent QH301-705.5 Science FACIOBRACHIAL DYSTONIC SEIZURES Amnesia MINI-MENTAL-STATE AUTOBIOGRAPHICAL MEMORY 050105 experimental psychology General Biochemistry Genetics and Molecular Biology Autoimmune Diseases 03 medical and health sciences limbic encephalitis medicine Humans 0501 psychology and cognitive sciences Biology Aged Forgetting Science & Technology General Immunology and Microbiology Recall business.industry LOW-FREQUENCY FLUCTUATION MEDIAL TEMPORAL-LOBE cingulate medicine.disease 030104 developmental biology nervous system Atrophy Nerve Net business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| ISSN: | 2050-084X |
| Popis: | Patients with hippocampal amnesia play a central role in memory neuroscience but the neural underpinnings of amnesia are hotly debated. We hypothesized that focal hippocampal damage is associated with changes across the extended hippocampal system and that these, rather than hippocampal atrophy per se, would explain variability in memory between patients. We assessed this hypothesis in a uniquely large cohort of patients (n=38) after autoimmune limbic encephalitis, a syndrome associated with focal structural hippocampal pathology. These patients showed impaired recall, recognition and maintenance of new information, and remote autobiographical amnesia. Besides hippocampal atrophy, we observed correlatively reduced thalamic volume, resting-state inter-hippocampal connectivity and activity in posteromedial cortex. Associations of hippocampal volume with recall, recognition, and remote memory were fully mediated by wider network abnormalities, and were only direct in forgetting. Such network abnormalities may explain the variability across studies of amnesia and speak to theoretical debates in memory neuroscience. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|