Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains
| Autor: | Maria Milene Costa da Silva, Wanderlei do Amaral, Raimundo Luiz Silva Pereira, Cristina Rodrigues dos Santos Barbosa, Ana Carolina Justino de Araújo, Janaína Esmeraldo Rocha, Débora Feitosa Muniz, José Bezerra de Araújo Neto, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Luiz Everson da Silva, Priscilla Ramos Freitas, Cícero Deschamps, Saulo R. Tintino |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.drug_class 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology law.invention 03 medical and health sciences Minimum inhibitory concentration law medicine Oils Volatile Essential oil Traditional medicine biology Pseudomonas aeruginosa Baccharis Chemistry biology.organism_classification Anti-Bacterial Agents Plant Leaves 030104 developmental biology Infectious Diseases Phytochemical Staphylococcus aureus Antibacterial activity |
| Zdroj: | Microbial pathogenesis. 145 |
| ISSN: | 1096-1208 |
| Popis: | Essential oils are secondary metabolites with immense pharmacological potential.These substances are abundantly produced by plants of the family Asteraceae, such as Baccharis coridifolia. Previous studies have demonstrated that this species has pharmacological properties that make it a promising source of new antibacterial agents. Therefore, the present study aimed to evaluate the antibacterial and antibiotic-modulating activity of Baccharis coridifolia essential oil against multidrug-resistant (MDR) strains. The phytochemical analysis was carried out by gas chromatography coupled to Mass Spectroscopy (GC/MS), and realized the Minimum Inhibitory Concentation (MIC) and antibiotic-modulation from the microdilution method in 96-well plates. It was revealed the presence of germacrene D (23.7%), bicyclogermacrene (17.1%), and (E)-caryophyllene (8.4%) as major components. The minimum inhibitory concentration of essential oil against strains of Pseudomonas aeruginosa (512 μg/mL) and Staphylococcus aureus (128 μg/mL) demonstrated clinically relevant antibacterial activity. In addition, the combination of subinhibitory doses of the oil with conventional antibiotics showed synergism, indicating potentiation of the antibacterial effect. In conclusion, the essential oil of Baccharis coridifolia (EOBc) presented antibacterial and antibiotic-modulating activities that place this species as a source of molecules useful in the fight against bacterial resistance. |
| Databáze: | OpenAIRE |
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