Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens
| Autor: | John C. Roder, Ping Su, Rafael K. Varaschin, Albert H.C. Wong, Bernard Le Foll, Louis-Eric Trudeau, Caleb J. Browne, Fang Liu, Enoch Ng, Olaf Pongs, Joanna Hermainski |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Dopamine Conditioning Classical Neuronal Calcium-Sensor Proteins Striatum Motor Activity Nucleus accumbens Biology Satiety Response behavioral disciplines and activities Nucleus Accumbens Tissue Culture Techniques Food Preferences 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Dopamine receptor D1 Dopamine receptor D3 Dopamine receptor D2 mental disorders medicine Animals Mice Knockout Motivation Neuropeptides Dopaminergic Feeding Behavior Mice Inbred C57BL Amphetamine 030104 developmental biology Neuronal calcium sensor-1 biology.protein Central Nervous System Stimulants Neuroscience Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural Brain Research. 301:213-225 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2015.12.037 |
| Popis: | Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synaptic plasticity and learning. NCS-1 interacts with and regulates dopamine D2 receptor (D2R) internalization and is implicated in disorders like schizophrenia and substance abuse. However, the role of NCS-1 in behaviors dependent on dopamine signaling in the striatum, where D2R is most highly expressed, is unknown. We show that Ncs-1 deletion in the mouse decreases willingness to work for food. Moreover, Ncs-1 knockout mice have significantly lower activity-dependent dopamine release in the nucleus accumbens core in acute slice recordings. In contrast, food preference, responding for conditioned reinforcement, ability to represent changes in reward value, and locomotor response to amphetamine are not impaired. These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior. |
| Databáze: | OpenAIRE |
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