Association Study Between the Pericentrin (PCNT) Gene and Schizophrenia
| Autor: | Mitsuo Itakura, Masatoshi Takeda, Kazutaka Ohi, Ryota Hashimoto, Toshihito Tanahashi, Shu-ichi Ueno, Masahito Nakataki, Shusuke Numata, Jun-ichi Iga, Tetsuro Ohmori, Yoshihiro Nakadoi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Genotype Nerve Tissue Proteins Genome-wide association study Single-nucleotide polymorphism Biology Bioinformatics Polymorphism Single Nucleotide Cellular and Molecular Neuroscience DISC1 Gene Frequency PCNT Humans Genetic Predisposition to Disease Antigens Allele Allele frequency Genetic association Genetics Haplotype Middle Aged Haplotypes Neurology Case-Control Studies Schizophrenia biology.protein Molecular Medicine Female Genome-Wide Association Study |
| Zdroj: | NeuroMolecular Medicine. 12:243-247 |
| ISSN: | 1559-1174 1535-1084 |
| DOI: | 10.1007/s12017-009-8106-x |
| Popis: | Disrupted-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia (SZ) and major depressive disorder (MDD), interacts with several proteins and some of them are reported to be genetically associated with SZ. Pericentrin (PCNT) also interacts with DISC1 and recently single-nucleotide polymorphisms (SNPs) within the PCNT gene have been found to show significant associations with SZ and MDD. In this study, case-controlled association analysis was performed to determine if the PCNT gene is implicated in SZ. Nine SNPs were analyzed in 1,477 individuals (726 patients with SZ and 751 healthy controls). No significant difference was observed between the controls and the patients in allelic frequencies or genotypic distributions of eight SNPs. Although allelic distribution of rs11702684 was different between the two groups (P = 0.042), the difference did not reach statistical significance after permutation correction for multiple comparisons. In the haplotypic analysis, we could not find any significant association in our subjects, either. This gene may not play a major role independently in the etiology of SZ in the Japanese population. |
| Databáze: | OpenAIRE |
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