Major Risk Factors in Head and Neck Cancer: A Retrospective Analysis of 12-Year Experiences
| Autor: | Ashok K Chauhan, Vivek Kaushal, Rajeev Atri, Rakesh Dhankhar, Anil Kumar Dhull |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty LAHNC Locally advanced 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Retrospective analysis Basal cell Head and neck cancer (HNC) Head and neck business.industry Smoking Head and neck cancer Cancer 030206 dentistry Lifestyle medicine.disease Increased risk Risk factors 030220 oncology & carcinogenesis Original Article Alcohol business Alcohol consumption Carcinogen |
| Zdroj: | World Journal of Oncology |
| ISSN: | 1920-454X 1920-4531 |
| DOI: | 10.14740/wjon1104w |
| Popis: | Background: Head and neck cancer (HNC) is the seventh most common type of cancer in the world and constitute 5% of the entire cancers worldwide. The global burden of HNC accounts for 650,000 new cases and 350,000 deaths worldwide every year and a major proportion of regional malignancies in India. More than 70% of squamous cell carcinoma of the head and neck are estimated to be avoidable by lifestyle changes, particularly by effective reduction of exposure to well-known risk factors such as tobacco smoking and alcohol drinking. Methods: A retrospective analysis of 12 years (2001 - 2012) of HNC patients attending RCC, PGIMS Rohtak was done. Total numbers of cancer patients seen were 26,295 and out of these 9,950 patients were of HNCs, which were retrospectively analyzed for their associated risk factors in different HNC subtypes. Most of the patients, i.e. 92.3%, were presented as locally advanced HNC (stages III and IV). Results: It has been observed that smoking and alcohol are the strongest independent risk factors responsible for increased risk of HNC and are further having synergetic correlations. Conclusion: The present study confirms the principal role of alcohol consumption and smoking in HNC carcinogenesis, as well as the differential associations with HNC subtypes, and a significant, positive, multiplicative interaction with different risk factors. World J Oncol. 2018;9(3):80-84 doi: https://doi.org/10.14740/wjon1104w |
| Databáze: | OpenAIRE |
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