Increased responses in the somatosensory thalamus immediately after spinal cord injury
| Autor: | Desire Humanes-Valera, Elena Alonso-Calviño, E. Fernández-López, Juan Aguilar, I. Martínez-Camero, Guglielmo Foffani |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male animal structures Stimulation Hindlimb Spinal cord injury Somatosensory system lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory Physical Stimulation Forelimb medicine Animals Rats Wistar lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Spinal Cord Injuries Neurons Ventral Thalamic Nuclei business.industry Thalamocortical plasticity Anatomy Somatosensory Cortex medicine.disease Peripheral Electrophysiology Spontaneous activity Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neurology Nucleus ventralis posterior lateralis of the thalamus Evoked responses business Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Disease, Vol 87, Iss, Pp 39-49 (2016) |
| Popis: | Spinal cord injury (SCI) involves large-scale deafferentation of supraspinal structures in the somatosensory system, producing well-known long-term effects at the thalamo-cortical level. We recently showed that SCI provokes immediate changes in cortical spontaneous and evoked responses and here, we have performed a similar study to define the immediate changes produced in the thalamic ventro-postero-lateral nucleus (VPL) that are associated with the forepaw and hindpaw circuits. Extracellular electrophysiological recordings from the VPL reflected the spontaneous activity and the responses to peripheral electrical stimulation applied to the paws. Accordingly, the activity of the neuronal populations recorded at specific thalamic locations that correspond to the forepaw and hindpaw circuits was recorded under control conditions and immediately after thoracic SCI. The results demonstrate that peripheral inputs from both extremities overlap on neuronal populations in the somatosensory thalamus. In addition, they show that the responses of thalamic neurons to forepaw and hindpaw stimuli are increased immediately after SCI, in association with a specific decrease in spontaneous activity in the hindpaw locations. Finally, the increased thalamic responses after SCI have a state-dependent component in relation with cortical activity. Together, our results indicate that the thalamic changes occurring immediately after SCI could contribute to the cortical changes also detected immediately after such spinal lesions. |
| Databáze: | OpenAIRE |
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