Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation
| Autor: | Satomi Omotehara, Yusuke Kudo, Takanori Teshima, Takahito Iwai, Eiko Hayase, Junichi Sugita, Hitoshi Shibuya, Megumi Sato, Akio Shigematsu, Kaoru Kahata, Chikara Shimizu, Mutsumi Nishida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Scoring system Hepatic veno-occlusive disease Transplantation Conditioning medicine.medical_treatment Hematopoietic stem cell transplantation Paraumbilical vein 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Ascites medicine Humans Aged Ultrasonography Transplantation Univariate analysis business.industry Sinusoidal obstruction syndrome Hematology Blood flow Middle Aged medicine.disease 030220 oncology & carcinogenesis Female Radiology Color Doppler medicine.symptom business Complication 030215 immunology |
| Zdroj: | Biology of blood and marrow transplantation. 24(9):1896-1900 |
| ISSN: | 1083-8791 |
| Popis: | Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to univariate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts. |
| Databáze: | OpenAIRE |
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