Diabetic Foot Ulcers: A Neglected Complication of Lipodystrophy
| Autor: | Basak Ozgen Saydam, Melda Sonmez Ince, Ali Balci, Fatma Ela Keskin, Seher Kaya, Mehmet Eren, Onur Saydam, Canan Altay, Firat Bayraktar, Gulcin Akinci, Habib Bilen, Murat Dagdeviren, Elif A. Oral, Cem Suleyman Adiyaman, Baris Akinci |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Turkey Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Congenital generalized lipodystrophy Cohort Studies Diabetes Complications 03 medical and health sciences Diabetes mellitus genetics Young Adult 0302 clinical medicine Lipodystrophy Congenital Generalized Internal medicine Internal Medicine medicine Diabetes Mellitus Humans 030212 general & internal medicine Age of Onset Aged Retrospective Studies Advanced and Specialized Nursing business.industry Generalized lipodystrophy Partial Lipodystrophy Retrospective cohort study Middle Aged medicine.disease Familial partial lipodystrophy Prognosis Diabetic foot Diabetic Foot Disease Progression Female Lipodystrophy business |
| Popis: | Lipodystrophy is a group of rare disorders characterized by generalized or partial loss of adipose tissue. Diabetes secondary to lipodystrophy is hardly responsive to standard treatment modalities and may lead to microvascular and macrovascular complications (1). Diabetic foot ulcers (DFUs) are a chronic complication of diabetes and a leading cause of lower-limb loss due to amputations. DFUs are an important cause of diabetes-related mortality (2). In this observational retrospective cohort study, we report on 18 DFU episodes that developed in metreleptin-naive patients with lipodystrophy. These DFU episodes were compared with a series of DFUs ( n = 399) that occurred in a well-established cohort of patients with type 2 diabetes ( n = 290). The study was approved by the Dokuz Eylul University ethical review board. Among 206 patients with lipodystrophy registered in our national cohort, DFUs were observed in 9 of 90 subjects with diabetes (10%). Four of these patients (44.4%) had multiple DFU episodes. Six patients had generalized lipodystrophy: five congenital generalized lipodystrophy (CGL) type 1 caused by AGPAT2 p.R68X (c.202C>T), p.E229X (c.685G>T), p.K216X (c.646A>T), and p.D180PfsX5 (c.538_539delGA) variants, and one CGL type 2 caused by BSCL2 p.Q94X (c.280C>T) variant. Three patients had partial lipodystrophy: one familial partial lipodystrophy (FPLD) type 1, one FPLD type 2 caused by LMNA p.R482W (c.144C>T) variant, … |
| Databáze: | OpenAIRE |
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