Metal ions modulation of the self-assembly of short peptide conjugated nonsteroidal anti-inflammatory drugs (NSAIDs)
| Autor: | Chunying Chen, Yuan Gao, Jiaming Liu, Jiayang Li, Zeinab Farhadi Sabet, Min You, Xiaomei Ma, Yaling Wang, Wenjiao Fu, Huige Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
Ions
chemistry.chemical_classification Aqueous solution Dipeptide Chemical substance Metal ions in aqueous solution Anti-Inflammatory Agents Non-Steroidal Nanofibers Temperature Hydrogels Peptide Dipeptides Hydrogen-Ion Concentration Conjugated system Combinatorial chemistry chemistry.chemical_compound chemistry Metals Thermogravimetry Self-healing hydrogels Molecule General Materials Science Rheology |
| Zdroj: | Nanoscale. 12:7960-7968 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/d0nr00572j |
| Popis: | Metal ions are essential components that help maintain the processes of normal life, and they can be used to fabricate self-assembled building blocks for peptide derivatives, proteins and nucleic acids. Here, we have developed a novel strategy to construct supramolecular hydrogels modulated using metal cations. Upon introducing a variety of metal ions into aqueous solutions of a gelator (naproxen-FF), including a nonsteroidal anti-inflammatory drug (NSAID) and dipeptide, we obtain stable hydrogels under neutral or alkaline conditions. It is found that these hydrogels with three-dimensional nanofiber networks exhibit excellent mechanical properties and thixotropy, as well as superb responsivity to multiple metal ions. Due to the significance of potassium ions in biological processes, the K-triggered hydrogel has been chosen as a model, and its self-assembly mechanism has been explored via various spectral analysis processes. In addition, the self-assembly performances of peptides are significantly affected by the chemical structures of the gelator molecules. This work provides deep insight into the aggregation mechanism of dipeptide-conjugating drug molecules through introducing a variety of metal ions, laying the foundation for further biological applications. |
| Databáze: | OpenAIRE |
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