Perioperative Dexmedetomidine Reduces Delirium in Elderly Patients after Lung Cancer Surgery
| Autor: | Ting Huyan, Hourong Peng, Zheng Zhu, Xuejiao Hu, Wei Zhang, Qi Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
China
Lung Neoplasms Dexmedetomidine delirium elderly patients lung cancer surgery behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Emergence Delirium Postoperative Complications Intensive care mental disorders medicine Humans Hypnotics and Sedatives Lung cancer Aged Retrospective Studies Lung cancer surgery business.industry Delirium Retrospective cohort study General Medicine Perioperative medicine.disease nervous system diseases 030227 psychiatry Psychiatry and Mental health Emergence delirium Anesthesia medicine.symptom business medicine.drug |
| Zdroj: | Psychiatria Danubina Volume 31 Issue 1 |
| ISSN: | 0353-5053 |
| Popis: | Background: Delirium, which is one of the most disturbing postoperative complications in elderly patients, shows high morbidity in patients undergoing lung cancer surgery. Dexmedetomidine (DEX) is considered a potential prophylactic agent for preventing patients’ delirium after lung cancer surgery.Subjects and methods: Medical records of lung cancer patients over 65 years old with radical pulmonary resection at Henan Provincial People’s Hospital from January 2015 to December 2017, China, were evaluated. Patients, care-providers, and investigators were all blinded to group assignment. DEX was administered in the preoperative and intraoperative periods. The incidence of delirium was calculated based on the Intensive Care Delirium Screening Checklist (ICDSC). Scores of ≥4 and 1-3 points represent the diagnoses of delirium and a pre-delirious state, respectively.Results: During postoperative day 1(POD 1) to POD 7, delirium occurs in both groups. During postoperative POD 1 to POD 7, the incidence of delirium is lower in the DEX group than that in the control group. Furthermore, there are more mild delirium patients but fewer moderate and severe delirium patients in the DEX group compared with the control group. Finally, patients in the DEX group have a shorter duration of delirium, lower numeric pain rating scale during movement and better sleep quality.Conclusion: Preoperative and intraoperative application of DEX can reduce the incidence and intensity of delirium after pulmonary resection in elderly patients with lung cancer. |
| Databáze: | OpenAIRE |
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