Inhibitory Effect of Extracts of Brazilian Marine Algae on Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Induced Syncytium Formation In Vitro

Autor:	Wigg, Maria Teresa Villela Romanos, dos S, A. A. Ribeiro, Yocie Yoneshigue-Valentin, Sônia Soares Costa, Andrada-Serpa Mj
Rok vydání:	2002
Předmět:	Cancer Research viruses Lymphocyte Cell Communication Virus Replication Giant Cells Microbiology HeLa Cytopathogenic Effect Viral Algae medicine Humans Cytotoxic T cell Human T cell lymphotropic virus type 1 Human T-lymphotropic virus 1 Syncytium biology Algal Proteins Dextran Sulfate Eukaryota virus diseases Biological activity General Medicine biology.organism_classification Virology In vitro medicine.anatomical_structure Oncology K562 Cells Brazil HeLa Cells
Zdroj:	Cancer Investigation. 20:46-54
ISSN:	1532-4192 0735-7907
DOI:	10.1081/cnv-120000365
Popis:	Extracts from four species of Brazilian marine algae collected from the Rio de Janeiro State coast were screened to determine the inhibitory effect on HTLV-1-induced syncytium formation. Before performing the syncytium inhibition assay the 50% cytotoxic dose (CyD50) of the algal extracts was evaluated. The antiviral test was carried out in HeLa cells co-cultured with HTLV-I infected T-cell line (C91/PL cells) in the presence of marine algal extracts in the concentration inferior to that corresponding to the CyD50. It was observed that co-cultured cells exposed to Ulva fasciata extract showed 60.2% syncytium inhibition at a concentration of 2.5%. At 5% concentration, Sargassum vulgare and Vidalia obtusiloba extracts presented 78.8 and 76% syncytium inhibition, respectively. The best inhibitory activity was observed with Laminaria abyssalis that presented 100% syncytium inhibition at a concentration of 2.5%. This work shows that extracts of marine algae, mainly L. abyssalis extract, are able to inhibit the cell-to-cell contact essential for the spreading of the virus and could be useful to prevent the infection.
Databáze:	OpenAIRE
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